Summary: Ubiquitination controls numerous cellular processes, and its deregulation is associated with many pathologies.The Nse1 subunit in the Smc5/6 complex contains a RING domain with ubiquitin E3 ligase activity and essential functions in genome integrity.However, Nse1-dependent ubiquitin targets remain elusive.Here, we use label-free quantitati
The Central American nations of Guatemala, Honduras and Nicaragua are among the poorest in the Americas.While the fraction of population dependent on solid fuels has declined in these nations over the last 25 years, the number of people using them has risen.Here, we first assess current patterns of cooking energy use in these nations.We then apply
The article for the first Wheat Germ Oil time in the Russian Humanities considers the phenomenon of glamour through the prism of universal aesthetic categories.The essence of the conception is to explore the phenomenon of glamour not in the sphere of its existence, but to perform global ontological phenomena to which its genesis leads.Following the
The article considers main historical stages of the establishment and development of insurance supervision system in Russia and Ukraine.The objective necessity and the essence of state regulation of insurance business, its Puree basic directions and methods providing a combination of interests of policyholders, the state and insurance companies are
We performed a genome-level computational study of sequence and structure similarity, the THROAT SPRAY latter using crystal structures and models, of the proteases of Homo sapiens and the human parasite Trypanosoma brucei.Using sequence and structure similarity networks to summarize the results, we constructed global views that show visually the re